Pathophysiology of Hepatic Injury due to liver fibrosis: Diagnosis and management

Abstract

Liver fibrosis and cirrhosis are result of chronic liver injury, which leads to an excessive accumulation of extracellular matrix proteins (ECM). If untreated, this stage can aggravated to severe complications like liver failure and hepatocellular carcinoma. In depth analysis of liver fibrosis diagnosis, treatment and emphasizing of various causes i.e. genetic disorders, viral infections, dietary influences and exposure of foreign substances. Innovations in diagnostic methods, particularly non-invasive imaging techniques that are Fibro Scan, Transient elastography and alongside biomarker assessments have increased early detection capabilities. Now modern therapies are including antifibrotic medications, antiviral therapies and modification of lifestyles. They have contributed better prognosis for patient. This chapter underscores the necessity of a multidisciplinary approach that combines recent diagnosis, therapeutic strategies and obstructive measures to inhibit disease progression. It aims to equip researchers and medical professionals with a thorough understanding of current liver fibrosis management.

Keywords: Liver; Collagen; Fibrosis; Cirrhosis; Therapy; Diagnosis